The purpose of this study was to find out the influence of career guide on girl child career choices in selected secondary schools in Mbeya City, Tanzania. The objectives were to find out how parents’ career influence female students’ future and to establish the influence of career guidance in female students’ career choices after secondary school in selected secondary schools. The research employed descriptive research design with both quantitative and qualitative research approaches. Data was collected from 150 girl students using a self-administered questionnaire. The findings showed that parents have much influence on children’s choice of educational career as stated by 107(71.3%) respondents. 121(80.6%) respondents agreed also that higher occupational parents would want their child to be doctors, engineering etc. without considering the ability of a child. Also, 120(80.6%) respondents reveal that teachers career guidance guide influence in female students’ career choices after secondary. Based on the study findings, the research concluded that parent’ career influence female students’ future career choice after secondary school in selected secondary schools in Mbeya City.