Studies are reported about leather after wearing, as leather experience various long-lasting deformations during manufacturing processes and wearing lifetime. Stress due to wearer movement is focused in different portions of leather garments such as knee, elbow, back line, seat, opposite shoulders etc. Goat and sheep leathers are investigated in this study, as they are the most popular leathers used in clothing field. The comparison of the dimensional change and water vapor permeability of sheep and goat leather is presented after different fatigue cycles and durations. Predicting the change of leather nature after fatigue cycles will improve designing of leather garments to provide comfortability and ergonomics to the wearer. The maximum number of stretching cycles was 260, and elongation percents varied in the range of 5%-25%. Goat leather has high recovery after stretching than sheep leather. Comparing the results obtained of water vapor permeability, it was observed that sheep leather has higher percentage than goat leather. The decrease in the water vapor per­meability of leather after a cyclic stretching was also reported. Three clothing designs are executed by adobe photoshop software proposed to produce with suitable leather type.