Background: Cancer diagnosis causes a huge impact on patients, their families and caregivers. To distract patients from unpleasant symptoms, music therapy can be included in the treatment. Objective: To assess the severity of depression in cancer patients pre and post music therapy using Patient Health Questionnaire-9 and Depression Anxiety Stress Scale-42. Design: Descriptive cross sectional study. Materials and Method: 30 participants were recruited; the severity of their depression was evaluated using PHQ-9 and DASS-42. Music therapy was given to the participants for 4 weeks for 20 minutes. Effects of the intervention were reassessed after 4 weeks Result: There was significant difference in mean values of severity of depression pre and post intervention as p value is <0.0001, measured using paired t test. Conclusion: Music therapy improved Quality of Life and mental health of the patients.