This study aimed to describe the Total Quality Management, Supply Chain Management, Competitive Advantage and Organizational Performance in manufacturing companies in Bogor, analyze the influence of Total Quality Management and Supply Chain Management of the Competitive Advantage in manufacturing companies in Bogor, analyze the influence of Total Quality Management and Supply Chain Management on Organizational performance in manufacturing companies in Bogor, analyzing the effect on Organizational performance Competitive Advantage in manufacturing companies in Bogor, and analyze the influence of Total Quality Management and Supply Chain Management on Organizational performance through Competitive Advantage in manufacturing companies in Bogor. This study is a quantitative research using the survey method. The population in this study is a manufacturing company which has obtained ISO 9000 certification for at least 1 year by 15 manufacturers. The number of samples was 165 people at 15 manufacturing companies. The sampling technique used is sampling based on purposive sampling. The analysis technique used is descriptive analysis and Analysis of Structural Equation Modeling (SEM). The analysis showed that the Total Quality Management and Supply Chain Management effect on Competitive Advantage in manufacturing companies in Bogor. Total Quality Management and Supply Chain Management on the performance of the organization at a manufacturing company in Bogor. Competitive advantage on the performance of the organization at a manufacturing company in Bogor. Competitive advantage to mediate the effect of Total Quality Management and Supply Chain Management on the performance of the organization.