Psychological trauma is one of the most prominent psychological problems every population confronts with. Understanding trauma is sometimes complex and comprehensive. Intrusive or painful experiences cause psychological trauma and it can influence the victim’s psychological, behavioural and emotional states and ultimately it can make an impact at biological level too. Hence this paper tries to understand the psychological trauma with the help of neuroscience research evidences. The paper is divided into three major parts which include neuro-endocrinal, neuro-chemical and neuro-anatomical consequences of trauma. As the three systems are interrelated and inseparable in functioning this classification is made only for better understanding.