This study was an attempt to see the level of drug side effects of adolescent patients with remitted bipolar affective disorder on treatment with clozapine and mood stabilizer. The present study was conducted at the Child and Adolescent Psychiatric Unit of Central Institute of Psychiatry (CIP), Ranchi. The present study was a cross sectional hospital based study and used purposive sampling technique. The present study sample consisted of 40 adolescents, among which 20 were adolescent patients with bipolar affective disorder on treatment with clozapine and 20 were adolescent patients with bipolar affective disorder on treatment with mood stabilizer. The following tools were used for the current study: Socio-demographic data sheet and self-prepared questionnaire for assessing drug side effects. The study result indicates that clozapine may be a better alternative to mood stabilizers when medication related adverse drug effects are considered in adolescent patients with bipolar affective disorder.