A field experiment was conducted during December, 2015 – March, 2016 kharif season. It carried out at the research farm of Department of Soil Science, Sam Higginbottom Institute of Agriculture, Technology and Sciences, (Deemed–to-be-University) Allahabad, India and studied the Effect of different Levels of Chemical Fertilizers on Soil Health and Yield of Maize (Zea mays L.). The experiment was laid out (RBD) Sample Randomize Block Design with three replication and fertilizers are used in different levels. Nitrogen (120, 90,50,0 kg/ha), phosphorus (60, 45,30,0 kg/ha), potassium (40, 30, 20, 0) are applied under sandy loam soil. The result shows that application Inorganic fertilizers increased soil chemical properties but some parameters of soil physical properties decreased. It was recorded from the application of chemical fertilizers in treatment T₁ (120kg N ha^-1, 60 kg P ha^-1, 20kg K ha^-1) improved nitrogen. Available phosphorus was found more in T₅(60kg N ha^-1, 60kg P ha^-1, 20kg K ha^-1), followed by T₂ (90kg N ha^-1, 45kg P ha^-1 ). The physical and chemical parameters of soil such as bulk density and particle density increased however pores space, EC decreased.