Early blight is one of the most common and devastating disease of potato plant which is caused by the fungus, Alternaria solani. The antifungal activity of five plants extracts namely Azadirachta indica (Neem), Eucalyptus chamadulonsis (Eucalyptus), Ocimum tenuiflorum (Tulsi), Nerium oleander (Kaner), and Calotropis procera (Madar) at 10 % concentration and Carbendazim 0.1% concentration as a treated check, was tested for management of Alternaria solani in vitro and in vivo. In the present investigation the highest inhibition of mycelial growth of Alternaria solani was achieved by fresh aqueous extract of Eucalyptus chamadulonsis, Ocimum tenuiflorum, and Azadirachta indica caused the highest reduction of mycelial growth of A. solani (57.35, 50.0 and 44.12%, respectively), while Nerium oleander, and Calotropis procera caused the lowest inhibition of mycelial growth of the pathogen as compare to treated check and untreated check. In field experiments, the highest reduction of disease severity was achieved by applying the extracts of Eucalyptus chamadulonsis and Ocimum tenuiflorum, at 10% concentration (35.80%, 45.68%) as compare to treated check carbendazim at 0.1% concentration (25.93%). and treated check T₀ (95.06%). All treatments significantly reduced the early blight disease severity as well as increased the plant height number of branches and yield of potato compared to the infected control under field conditions, Thus the present study revealed that plant extracts have shown significant inhibition and proved to be cost effective and eco-friendly for the management of A. solani and were comparable with fungicides.