Myocardial infarction (MI) is the leading cause of mortality and morbidity in present days. It is a common presentation of ischemic heart disease. Myocardial Ischemia is characterized by an imbalance between myocardial oxygen supply and demand. Unrelieved Ischemia produces cell death what is pathologically known as necrosis. Magnesium is the fourth most common cation found in the body and the second most common intracellular cation. C-reactive protein (CRP) is a hepatic acute phase reactant. The study group consisted of 120 subjects, of age groups 20-60 years and of both sexes. Of these, 40 were STEMI cases (Group 2), 40 were NSTEMI cases (Group 3) and 40 were healthy individuals as controls (Group 1). Serum hsCRP, Magnesium and Lipid profile were estimated in all the individuals. Results showed that the serum levels of hs CRP are increased in both Group 2 & Group 3 patients (Group 2 > Group 3) when compared to Group 1. Magnesium levels are decreased in both Group 2 & Group 3 patients (Group 2 > Group 3) when compared to Group 1. The changes in these parameters are extremely statistically significant in both groups when compared to controls (p < 0.0001). Hence they can be used as routine diagnostic tests along with other available biomarkers of MI.