For a long time, the Business English teaching in China tended to attach more importance to some professional fundamental knowledge and skills of commercial management and international trade and neglects relative cultivation of intercultural communication competence, the Business English students could not master well some basic knowledge and skills of intercultural communication in their professional career. Nowadays, it is a hot topic for teachers how to cultivate Business English students’ intercultural communication competence. Therefore, the author takes the course “Practice in Foreign Affairs” of Vocational and Technological School in China West Normal University as an example to indicate that it is an important approach to cultivate Business English students’ intercultural communication competence in the class. And then the paper mainly discusses how to use some different teaching methods to teach the Business English students in learning different cultures including different cultural customs and traditions and let the Business English students know some basic knowledge of various cultures from different countries, and train them basic skills how to communicate with different people from different cultural backgrounds, so as to really improve the Business English students’ intercultural communication competence in the teaching.