Increasing level of heavy metals in water represents a serious risk to human health and ecological system. Lead (Pb) is one of the metals that are extremely toxic to organisms even at low concentration. Biosorption is a biotechnical innovation and reliable method to remove Pb from solution using dried biomass of brown algae as adsorbent. The present work represents the biosorption of Pb from aqueous solution onto the biomass of Sargassum as a function of pH, temperature, biosorbent dosage and contact time. Results shows that maximum sorption was found at pH 5.0, contact time of 60 min, temperature 25°C and dosage of 2.0 gm. Thus if above mentioned condition is provided Sargassum is considered as an ecofriendly, cost effective and potential adsorbent for biosorption of lead from aqueous solution.