Salman Rushdie, a British-Indian novelist and essayist, who combines magical and realistic details in his fiction and non-fiction, can be compared with English authors like E. L. Doctorow, Angela Carter, John Fowles, Peter Carey, Mark Helprin or Emma Tennant. His prose synthesizes imagery, ideas, and patterns of sound and sense. His literary works prove the versatility of his literary talent and his universal interest in probing the possibilities for a mutual understanding of cultures as different as those in the East and in the West. The Enchantress of Florence is Rushdie’s tenth novel published in 2008. The story of the novel is set against the background of Europe and the Orientals in the 16^th century. The novel seems to be historically accurate but conceived fictionally. It is rich in presenting minute details of the respective era, which is stylistically opulent. The influences on the novel could be compared with the writers like- Italo Calvino (Invisible Cities, if on a winter’s Night a Traveler), John Barth (Giles Goat-Boy, Chemera) and Gabriel Gracia Marquez (On Hundred Years of Solitude, The Autumn of the Patriarch). The novel concentrates upon the history of Mughal Era and Renaissance age; relationship between East and West; fantasy and fables; cross-cultural storytelling and journeying etc. Rushdie, like Garcia Marquez, intertwines actual historical characters and events within a story full of history, fantasy and fables. Moreover, the novel primarily concentrates on the mutual suspicion and mistrust between East (India’s Mughal Empire) and West (Renaissance Florence), Ottoman Empires, the earlier Mongols etc.