Introduction: Environmental pollution is “the contamination of the physical and biological components of the earth/ atmosphere system to such an extent that normal environmental processes are adversely affected” Aim: This study is conducted to assess the knowledge and attitude on effects of environmental pollution on human health among school children aged between 10-14 years. Materials and Methods: Descriptive research approach and survey research design were adopted to conduct the study in Camford public school at Tirupathi among 100 school children selected by simple random sampling technique. Data was collected using structured questionnaire. Data was analyzed using descriptive and inferential statistics. Results: The study showed that mean knowledge score on general aspect of environmental pollution is 3.35 (41.87%), causes and sources of environmental pollution is 3.31 (39.12%), effects of environmental pollution mean score is 4.4 (40%), and mean score of 1.37 (34.25%) on preventive aspect of environmental pollution. Conclusion: Findings of the study showed that majority of the school children had inadequate knowledge i.e., 82% on effects of environmental pollution on human health.