Blood samples of albino rats treated with solvent extracts of leaf, bark and root of Vitellaria paradoxa were studied. The rats were grouped into A and B containing five rats each. Group a rats were given E. coli ATCC 25922 and ciprofloxacin while group B rats were given E. coli ATCC 25922 and treated with plant extract. The procedure was replicated for each test microorganism, each solvent extract and two dosages of the extract. The blood parameters significantly depended (p <0.05) on solvent of extraction and type of plant parts but not significantly (p >0.05) on type of tested microorganism nor on dosage of treatment with higher levels in rats treated with commercial antibiotics, methanol extracts, bark extracts and 50mg/ml concentrations. Rats treated with bark extracts have higher degree of disease resistance and are less likely to develop anaemia than those treated with other parts of V. paradoxa.