An experiment was conducted to assess the application mode of different commercial aqua drugs and chemicals in aquaculture activities and their impact on fish health. Thirty fish farms of Katiadi Upazila of Kishoreganj district were selected to observe the present status of use of commercial aqua drugs and chemicals and their impact on fish health. Data were collected through questionnaire interview with fish farmers, drug sellers, personal contact, market survey and representatives of pharmaceutical companies. Seven categories of aqua drugs and chemicals were identified that were used by fish farmers. Many companies include Fish Tech, ACI Animal Health, Square Pharmaceuticals Ltd, Renata Animal Health, Eon Fish Grower Ltd supplied those drugs. Different types of fish diseases were observed in the investigated areas. Farmers used various aqua drugs and chemicals such as Geotox, Zeolite, Mega Zeo, Oxyflow, Ammonil, Lime, Salt, Potassium permenganate, Sumithion, Formalin, Methylene blue, Malachite Green, Timsen, Oxysentin 20%, Captor, Aquqmycine, Megavit Aqua, Aqua Boost, Aqua Grow-P and ACmix Super -Fish against fish diseases and health problems of their cultured fishes. The results revealed that aqua drugs had a definite impact on the recovery of fish diseases that is 60% to 90% in various culture fishes of Kishoreganj region. The production values ranged from 6 to 14 tons/acre. In the present study water quality parameters were monitored and found to be within suitable range for freshwater aquaculture. During the field observation some problems were identified while using aqua drugs and chemicals which included poor understandings of farmers about the application of aqua drugs, inadequate withdrawal period and some adverse effects on fish and human health.