Chronic Hemodialysis was first introduced in 1960s to extend the lives of patient with end stage renal disease and by 1982, almost 1,00,000 patents throughout the world were being alive by some form of dialysis therapy. Dialysis removes many of the toxins responsible for the uremic syndrome and prolongs survival. However the dialysis treatment thus not fully correct the uremia and may be associated with treatment related complication mainly muscle cramps pain. The complication prevent patients from attaining a state of full health and interfere with many aspects of life. The degree to which an individual patient can adapt to their medical and psychological stresses is reflected in the quality of life of that individual. A world perspective on renal care, the challenges of prevention and treatment) says cramps are a common intra-dialytic event, the discomfort leads to premature termination of the treatment, noncompliance with the prescription and therefore under dialysis. This interfering with the muscle cramps and even preventing the occurrence become a major responsibility of the personal in charge of the patients. Since nurses are taking care of Hemodialysis patients almost everywhere it becomes predominantly the nurse’s role Muscle cramps are prolonged involuntary muscle contraction. To relieve an established cramp on must passively stretch the contracting muscle. Prophylactic stretching of the particular muscle can also prevent attacks.