The purpose of this work was to examine the effectiveness of plants oils for inhibition of growth of microorganisms by the paper disc agar diffusion method. Essential oils from (Clococynth , Lupin , Castor, Snak) were evaluated on two bacteria (B.subtilis and S.pyogenes ) and fungal species (A..niger ) and compared with standard antibiotic ampiciline. From the results , the four essential oils showed the greatest inhibition (inhibition zone from 29 to 15) mm to B.subtilis and ( inhibition zone from 25 to 12 )mm to S. . pyogenes and ( inhibition zone from 20 to 10 )mm to A.niger in minimum inhibitory concentration (MIC) ranged (50-100)µL\mL