Introduction: The efficiency of heart to eject greater amount of blood is known as cardiovascular efficiency. The functional capacity of the heart may be improved while the stroke volume and as a result cardiac output is enhanced. The cardiac output ensures the o2 supply according to the demand in a certain intensity of the nature of work he performed. The greater demand during certain activity greater is the cardiac output according to his cardiovascular efficiency. Purpose: To compare cardiovascular efficiency of smoker and fnon-smoker of adult age. Methods: Thirty adult males (15 Smokers and 15 Non-Smokers), ages 21-25 years, volunteered to serve as subjects of the study. Cardio-vascular efficiency were the selected of the study. Independent ‘t’ test was used to examine the significant difference. The level of confidence was set at.05. Findings: The t-value of cardio-vascular efficiency [3.07 (<.05)], between smokers and non-smoker were found significant. Result: Mean value indicates that in cardio-vascular efficiency Non- smokers are better than smokers.