Background – to study significance of Csf C-Reactive Protein And Ada In Meningitis we done this study. Material and methods – total of 100 patients of meningitis admitted in department of medicine we included with specific inclusion and exclusion criteria and with ethical approval. Results –CSF CRP was significantly associated with pyogenic meningitis and raised with higher cell count, higher protein levels and lower CSF to blood glucose level, while CSF ADA was significantly raised in tubercular meningitis and higher CSF ADA levels were present in patients with higher cell count, and higher protein levels but no correlation was present between the ratio of CSF and blood glucose. Conclusion –CRP could be used as a marker of Pyogenic Meningitis and ADA for Tubercular meningitis.