Many infectious diseases are found to be associated with the human blood group antigens. In this study an attempt was made to find out the relation between filarial infection and human blood group. About 58 microfilaraemic, 95 subjects with elephantiasis and 378 endemic normal subjects were examined for their association with blood group antigens. About 45% microfilaraemic subject were found to have AB and about 42% subjects with elephantiasis were found to have B blood group.