Rheumatoid arthritis is an inflammatory joint disease characterised by multiple deformities and associated with considerable morbidity and mortality. The combination of IgM RF and anti ccp antibody increase the ability to detect RA early and to prevent erosive and progressive disease. 50 patients with RA and 50 non RA patients were included in the study. Serum were tested for RA and Anti ccp antibody by latex agglutination test and ELISA respectively. RF was positive in 34(68%)of RA and 15(30%)of non RA. Anti ccp antibody was positive in 38(76%)of RA and 1(2%)of non RA. The sensitivity of RF was 68% and specificity of was 73%.The sensitivity and specificity of Anti ccp antibody was 76% and 97% respectively. Anti ccp antibody testing combined with RF has additional value in the diagnosis of RA over RF alone.Anti ccp antibody detection proved to be a powerful diagnostic tool especially in sero negative arthritis.