The role of Zn in the induction of systemic inflammation in obesity and obesity related diseases has been documented. Excessive Zn in diet was found to increase the subcutaneous fats resulting higher gain in body weights resulting obesity. The present study revealed that Zn- induced obesity leads to systemic inflammation. TNF- ? is directly related to concentration of Zn in tissues, insulin and correlating leptin levels causes insulin and leptin resistance which have been linked to the fall in antioxidant enzyme activities including superoxide dismutase and catalase due to Cu-deficiency in the tissues leading to rise in liver lipid peroxidation reactions pertaining to increased outcome of oxidative stress.