International Journal of Multidisciplinary Research and Development

International Journal of Multidisciplinary Research and Development


International Journal of Multidisciplinary Research and Development
International Journal of Multidisciplinary Research and Development
Vol. 2, Issue 12 (2015)

Studies on systemic inflammatory marker, TNF- α and oxidative stress in Zn induced obese wistar rats


Saveena Bogtapa, Reshu Mandal, Satish Kumar Taneja

The role of Zn in the induction of systemic inflammation in obesity and obesity related diseases has been documented. Excessive Zn in diet was found to increase the subcutaneous fats resulting higher gain in body weights resulting obesity. The present study revealed that Zn- induced obesity leads to systemic inflammation. TNF- ? is directly related to concentration of Zn in tissues, insulin and correlating leptin levels causes insulin and leptin resistance which have been linked to the fall in antioxidant enzyme activities including superoxide dismutase and catalase due to Cu-deficiency in the tissues leading to rise in liver lipid peroxidation reactions pertaining to increased outcome of oxidative stress.
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How to cite this article:
Saveena Bogtapa, Reshu Mandal, Satish Kumar Taneja. Studies on systemic inflammatory marker, TNF- α and oxidative stress in Zn induced obese wistar rats. International Journal of Multidisciplinary Research and Development, Volume 2, Issue 12, 2015, Pages 253-257
International Journal of Multidisciplinary Research and Development International Journal of Multidisciplinary Research and Development