Present Study was carried out to evaluate Prescription Patterns on CNS disorder with Respect to Depression, Sleep Disorder, and Mood Disorder. Total 186 prescriptions were collected from the medical practitioners as well as from patients and distributed for three diseases for Depression (n=83), Mood disorder (n=83) and Sleep disorder (n=20) from study centre Nashik. Prescription evaluated using WHO indicator. In Depression among 59% of SSRIs the Escitalopram (29%) prescribed. TCAs (5.59%), Antipsychotics (18.01%) prescribed. In Mood disorder olanzapine and sodium valporate are mostly prescribed drugs. SSRIs (18.12%), TCA (5.84%), Atypical antipsychotics (24.56%), Aliphatic carboxylic acid (18.12%), Lithium (5.84%) prescribed. In sleep disorder Benzodiazepines are mostly prescribed (38.46%), Newer Benzodiazepine (20.51%), SSRIs (10.25%), TCAs (10.25%) and Barbiturates (5.12%) are prescribed. Study shows a shift from older to newer drugs and overall prescription pattern are good but drug prescribed by generic name very low.