Role of oral nifedipine in severe hypertension in pregnancy in comparison with intravenous labetalol in terms of drug efficacy
Dr. I Vani, Dr. K Bhavani, Dr. D Padmavathibai
Objective: To compare oral nifedipine with intravenous labetalol in rapidity of control of blood pressure in severe hypertension in pregnancy in terms of drug efficacy.
Study Design: A randomized clinical trial conducted at Department of Obstetrics and Gynaecology, King George hospital, Visakhapatnam.
Methods and Material: All antenatal mothers above 22 weeks period of gestation diagnosed as severe hypertension i.e. blood pressure > 160/110 mmHg are taken into the study. A total of 40 patients are randomly divided into two groups. Group-A received oral nifedipine 10mg tablets initially followed by 20mg (10, 20, 20, 20, 20mg) upto five doses every 20 minutes or until the target blood pressure of 150/100 mm of hg was achieved. Group-B received intravenous labetalol 20mg initially followed by 40mg in escalating doses (20, 40, 80, 80, 80mg) upto five doses every 15 minutes or until the target blood pressure was achieved. Crossover treatment was effected if initial treatment regimen was unsuccessful.
Result: The median time taken to achieve the target blood pressure was 30 minutes for oral nifedipine and40 minutes for intravenous labetalol. No crossover treatment was required in either group.
Conclusion: Both oral nifedipine and intravenous labetalol are similarly effective in control of severe hypertension in pregnancy.rn
Dr. I Vani, Dr. K Bhavani, Dr. D Padmavathibai. Role of oral nifedipine in severe hypertension in pregnancy in comparison with intravenous labetalol in terms of drug efficacy. International Journal of Multidisciplinary Research and Development, Volume 2, Issue 11, 2015, Pages 550-553