This paper investigated gender differences in the administration of secondary schools of Ebonyi state. In carrying out this study, three research questions were formulated to guide the study and three hypotheses were tested at 0.05 level of significant. The population of the study comprised of 232 public secondary school principals in Ebonyi state. Census was the sample technique employed. Also the study adopted descriptive survey research design since none of the variables was manipulated. A 28 item self-structured questionnaire was used as an instrument for data collection. This was structured in a 4 – point Likert option. The findings of the study revealed that male and female principals differ to a low extent in the administration of curriculum and instructional programme and personnel management but differ to a large extent in the administration of school plant. It was therefore recommended that government should organise the same in – service training for both male and female principals in the area of administration of curriculum and instructional programme and also expose them to the same styles of personnel management and should at the same time organize separate workshop for female principals as it relates to administration of school plants.