Maharashtra contributes around 10.4% to India’s textiles and apparels output. However it has covered highest area under cotton cultivation and 2nd largest producer of cotton in India. Maharashtra state has strong base of raw material for cotton textile industry. Around 70 to 80 lakh cotton bales produce per year out of which only 25 lakh bales consume by mills in the state. Near about 70% of raw cotton going to other states for next process. Thus it clearly reveals that inadequacy of spinning capacity in the state. All above things are considered in the present research paper to study scope, sustainability and prospects of cotton textile industry in Maharashtra state. The cotton profile of Maharashtra and regional disparities in location of cotton textile industry are studied. There is ample scope to growth of cotton to cloth process including ginning units, spinning mills, composite mills, garments units. Further processing such as sizing, dyeing, printing, finishing etc. establish for value addition in grey cloth; would be generate more employment in Maharashtra.