Student centered learning may provide more benefits for the students by offering learning sources and learning opportunities. It is expected that the students may directly experience and explore their knowledge to increase their skills of process. Objective of the research was to study whether the Guided Inquiry learning and conventional learning may affect the students’ skills of process. Results of the research showed significant influence of learning strategy on skills of process between the control class (conventional learning) and experiment class (guided inquiry learning). Data showed that results of the test between subjects. Effects showed F_count4.584 and significance at 0.037. Meanwhile, F_table for df1:1 and df2:55 at significance level 95% was4.0162 because F_count>F_table (4.584 > 4.0162) significance at 0.037 < 0.05.It showed that the guided inquiry learning strategy equipment improve learning results of the students’ skills of process.