This paper is an extract of reviewed literature for an on-going PhD study titled “Drug and Alcohol Abuse Prevention Education in Zambia’s secondary schools.” The background of the paper emanates from the fact that despite escalating incidences of drug and alcohol abuse among school going children, little is known concerning drug and alcohol abuse prevention practices and policies used in Zambia’s secondary schools. What is clear in the reviewed literature is that elsewhere in the world, literature shows that certain school-based prevention practices and policies such as skill-based content, interactive methods, use of trained teachers and professionals, high frequencies of lessons, timing, use of peer educators, involving family members and community leaders in drug and alcohol abuse prevention have proved to be effective in stopping, reducing, and delaying the onset of drug abuse behaviour among learners. The recommendation of this paper is that, if these strategic practices and policies have worked elsewhere in the world, they should be tried in Zambia.