International Journal of Multidisciplinary Research and Development

International Journal of Multidisciplinary Research and Development


International Journal of Multidisciplinary Research and Development
International Journal of Multidisciplinary Research and Development
Vol. 1, Issue 2 (2014)

Kinetic estimation of discrepancy between rats and humans regarding the immunological response to MGN-3/Biobran


Yeh Chen, Hui-Er Wang, Jing-Gung Chung, Robert Y. Peng

The interaction of MGN-3/Biobran in vivo in activating immune response is quite complicated and different between the rats and human. We analyze the major routes of this interaction kinetically and a cytokine mediated model (CMM) is developed to evaluate such a crucial discrepancy between the two biological systems. Rats responded with a kinetic order 1/3, while that of human was 1/24 regarding both MGN-/Biobran and INF-, compared to the predicted value 1/2. As well known, a higher reaction order implicates the more complicate reaction among the reactants. Alternatively, the Monod model gave values of Ks 1.43 and 2.44 mg/kg, and those of Vmax 32.36 and 227.27%/day respectively for rats and human. Apparently, the immunological response of rats was more complicate than human in view of MGN-3/Biobran therapy. We conclude that the discrepancy in the immuno-response between rat and human can reach 3000 folds due to the inter-species variation. We suggest that such differences should be taken into account when using mice or rats as preclinical models of human disease.
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