International Journal of Multidisciplinary Research and Development

International Journal of Multidisciplinary Research and Development


International Journal of Multidisciplinary Research and Development
International Journal of Multidisciplinary Research and Development
Vol. 6, Issue 4 (2019)

Hepatoprotective potential of ethanolic leaf extracts of Carica papaya and Newbouldia laevis on alloxan-induced diabetic wistar rats


Ifegwu NO, Anibeze CIP, Ndukwe GU, Njoku-Oji NN, Agbai JU, Opara JK, Asebioyo SK

Objective:This study was carried out to investigate the effect of the ethanolic leaf extracts of C. papaya and N. laevis on the liver enzymes of alloxan-induced Wistar rats. Methodology: Forty male Wistar rats weighing between 160g – 200g were randomly assigned to eight Groups A - H of 5 rats each. Group A served as the control group and was not induced with diabetes, while Groups B – H were induced. Groups A and B received distilled water only, while Groups C - H received 200mg/kg of C. papaya, 400mg/kg of C. papaya, 200mg/kg of N. laevis, 400mg/kg of N. laevis, 200mg/kg of C. papaya + 200mg/kg of N. laevis and 400mg/kg of C. papaya + 400mg/kg of N. laevis respectively for 28 days. On day 29 of the experiment, the animals were weighed and sacrificed; and blood samples were collected from each of the animals for serum analysis. Results: There were significant (P?0.05) decrease in body weight and significant (P?0.05) increase in serum levels of ALT, AST and ALP of the animals in group B when compared with the control group. These effects were ameliorated in Groups C - H which received the variable doses of the ethanolic leaf extracts with more positive effects on the Groups that received the combined ethanolic leaf extracts. Conclusion: The leaf extracts of C. papaya and N. laevis have ameliorative effects on the body weight and serum levels of ALT, AST, and ALP of alloxan-induced Wistar rats.
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