Effect of Alstonia congensis Engl. extract on early and established plasmodial infection
Nmezi S N, Ubah V C S, Nwoko M C, Ukaga C N, Ajero C M U
This study was conducted to investigate the effect of leaf, bark and root of Alstonia congensis on early and established infections of Plasmodium berghei in animal models. The study was carried out between March 2015 to April 2017. A. congensis was collected from Emekuku area of Imo State, while P. berghei was obtained from Institute of Advanced Medical Research and Training, University College hospital, Ibadan. The albino mice and rat were purchased from Animal Science and Production Department of Michael Okpara University of Agriculture, Umudike, Umuahia. Acute toxicity studies of the crude extracts were carried out in albino mice. The antiplasmodial activities during early and established infections were evaluated in the albino mice by examining the blood smear under a microscope. The extract of A. congensisthus possesses antiplasmodial activity and showed a dose-dependant chemosuppression and competed favourably with artesunate which was the control drug. There was no evidence of drug-induced symptoms at all the doses of the extract administered in acute study. The finding may support the traditional use of the plant to treat plasmodial infection (malaria). It would therefore, be worthwhile to purify active components by a bioassay guided isolation in order to assess the parasite life phase on which the plant extracts are most active.