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International Journal of Multidisciplinary Research and Development

ISSN Online: 2349-4182
ISSN Print: 2349-5979

Vol. 7, Issue 6 (2020)

Epidemiology of Parkinson’s disease in Libya

Author(s): Hatem fawzi Gharour, Andrew J bennett, Deborah J briggs, Salima M Hawda, Abdelhamid A Alzwawi, Shakila Srikumar, Peela Jagannadha Rao
Abstract: Background: Parkinson’s disease is characterized by dopaminergic neuronal loss in the substantia nigra at the central nervous system (CNS), a significant reduction in dopamine levels, and the presence of Lewy bodies Lewy bodies are composed of abnormal deposits of protein aggregates, particularly synuclein proteins. While the main etiology of the disease has yet to be determined. Environmental, occupational and genetic factors seem to play important roles Risk factor studies have pinpointed age, gender, occupation, area of residence, smoking, coffee/tea consumption, drinking well-water and being exposed to herbicides/pesticides. The prevalence of Parkinson's disease varies among ethnic and geographic groups around the world, being very low in countries of the far eastern asia and high in latin America, and varies in some areas in north africa and europe. Materials and Methods: An estimated 1%-2% over the age of 65 years are affected and more than 4% of the population by the age of 80 years. Information on socioeconomic background, diseases, medications and lifestyle was collected via questionnaires and interviews. History including age, sex, education, community population, occupation, coffee consumption, body mass index (BMI) {height and weight were measured, and the body mass index (kg/m2) was calculated. Results: The prevalence of Parkinsonim in this population was low, 44.12/100,000, while the prevalence in the age group above 60 years was 377.41/100,000. Below this age, the prevalence was low, 14.37/100,000. Parkinsonim prevalence was higher in males than in females (ratio 1.6:1); The prevalence was found to be higher in people who are living in rural areas, where most work in agriculture.The prevalence of Parkinsonim was low for residents living in the in the south (18.45/100,000) and higher to a lesser extent in the west (47.84/100,000), but was much higher in the east (61.22/100,000). Conclusion: In conclusion we found a high prevalence of Parkinsonim in the eastern area mainly in Benghazi, Al-Marg, Beida, Sussa, where the adult residents are agricultural workers. Epidemiological studies have pointed to an increased risk of Parkinsonim in farmers and agricultural workers those who continuously exposed to herbicides and pesticides. However, no conclusion has been drawn as to the specific agents that may be responsible.
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