Tinnitus has become one of the most challenging tasks faced by the medical field. It has a moderately negative impact on patient’s quality of life. Different methods had been developed in medical science for managing tinnitus but none of these offered a permanent cure. Objective: This study aims to evaluate the effect of intratympanic dexamethasone (8mg/2ml) injection in the treatment of refractory tinnitus associated with sensorinural hearing loss of cochlear origin. Methods: Total number of patients involved in this study are thirty patients complaining of tinnitus with sensorineural hearing loss, which were confirmed further by pure tone audiometry. Their ages ranged from 20-65 years with a mean of 42.5 years, Twenty four had unilateral tinnitus and six had bilateral tinnitus, the duration of tinnitus ranged from 3 months to 5 years. Injection was given under otologic microscopic vision and some patients by sinuscope 0 degree through posteroinferior quadrant of tympanic membrane in weekly interval for 4 weeks. The evaluations were done by tinnitus handicap inventory (THI) for all patients befor and in three sessions after intratympanic injection of dexamethasone, first after the end of all injection then at 3 months after injection and 6 months after injection. Results: Total percent of improvement of tinnitus after dexamethasone injection (76.7%), No improvment (23.3%). Conclusion: Intratympanic dexamethasone injection could be a simple noninvasive and effective method for the control of subjective tinnitus associated with sensorinural hearing loss.