Vol. 4, Issue 6 (2017)
Effect of menstrual cycle phases on plasma lipid and lipoprotein levels in regularly menstruating women
Author(s): Dr. Sana Fatima, Dr. RB Kamal, Manish Bajpai
Abstract: Introduction: Physiological cyclic variability in levels of sex
hormones during a menstrual cycle may possibly have an impact on lipids,
lipoprotein levels and therefore on cardiovascular health status of females.
To ascertain the effect of menstrual cycle phases
on the levels of cardiovascular risk predictors i.e., plasma lipids and
lipoproteins in healthy menstruating women.
and Methods: In the present study, 50
healthy regularly menstruating females aged 15-25 years were examined at two
points of a menstrual cycle i.e., in the follicular phase (10th day) and in the
luteal phase (22nd day) to find out the plasma levels of lipids and
lipoproteins. The data were statistically analysed using paired t-test.
A significant decrease in the mean levels of Total
Cholesterol (TC) (p<0.001), Low Density Lipoprotein Cholesterol (LDL-C)
(p<0.001), Very Low Density Lipoprotein VLDL (p<0.001) High Density
Lipoprotein Cholesterol (HDL-C) (p<0.001), Low Density Lipoprotein
Cholesterol (LDL)/ HDL (p<0.001), and Triglyceride TG(p<0.001) was
observed in the luteal phase compared to the follicular phase.
Conclusion: The present
findings reveal high levels of oestrogen in the luteal phase compared to
follicular phase of menstrual cycle. Clinicians should take menstrual cycle
phase in account when inferring a women biomarker measurement in the analysis
of cardiovascular diseases, particularly females possessing marginal levels.
Moreover research studies should take the menstrual cycle phase in
consideration which may be a confounding factor in framing and concluding
studies on reproductive age group women.