Vol. 4, Issue 12 (2017)
Non-compliance and associated factors leading to the prevalence of multi-drug resistant tuberculosis in Uganda
Author(s): Ssemanda Bosco, Amoah John K
Abstract: The study was done to identify the factors that lead to poor anti-tuberculosis drug compliance and to draw practical, cost-effective interventions to combat multi-drug resistant tuberculosis. Literature of peer reviewed journals, authoritative publications and relevant textbooks was done. Databases such as EBSCOHOST and HINARI were used to retrieve journal articles where only articles published from 2010-2017 were used. The articles were narrowed down to those that provided relevant information on factors affecting compliance to anti-TB drugs leading to MDR-TB in Uganda. The study showed that non-compliance was due to social/economic, health system/healthcare team, patient and therapy related factors. Three approaches to combat MDR-TB were drawn: community empowerment, strategic community education and promotion of research to develop enhanced therapeutic regimens. All factors linked with non-compliance are man-made and none is genetic linked. Approaches to combat MDR-TB should be geared toward increasing knowledge and change of attitudes, beliefs and practices relating to compliance at individual and institutional levels. Research is needed to assess whether there are pharmacokinetic variations among Ugandans, leading to antibiotic resistance. Assessment of knowledge level and attitude toward antibiotic resistance among Ugandan communities is also needed.