There is no doubt that as the time evolves, we observed the evolution not only in science but also in tradition. From classical to modern science, it has transformed a lot. Later on it was seen the influence of Vedanta in Science. With the successful theory of entanglement, the result discloses that elements are conscious and even interact with each other. They behave differently when someone is looking them closely. This quantum physics is compared with Advaita Vedanta (non-dualism) and M?dhyamika (school of Buddhism). This paper aim is to affirm the reality that in this globalized world everything is interdependent or relative in the universe. The disturbance in one can affect the other. It might be seen that the way of showing reality is different in all of them but ultimately, they are reaching at the same end.