International Journal of Multidisciplinary Research and Development

ISSN Online: 2349-4182
ISSN Print: 2349-5979

Article Icon NAAS Rating: 3
Vol. 3, Issue 5 (2016)

Post prandial lipid abnormalities in type 2 diabetes mellitus

Author(s): Dr. L Muralidhar, Dr. D Sridhar, Dr. G Balaraju
Abstract: It is increasingly believed that atherosclerosis is a postprandial phenomenon; high postprandial triglycerides have shown a strong independent association with CAD. Therefore measurement of lipids especially triglycerides in postprandial state would be more reliable and sensible indicator to predict future cardiovascular risk. This study was done in 50 patients with Type 2 Diabetes Mellitus and 50 age, sex and BMI matched healthy controls. Patients were on usual dose of oral hypoglycemic agents or insulin. Preliminary clinical and laboratory assessment was done in diabetic subjects and controls. After a 12 hrs over night fast standardized meal providing 600 kcals., was given to all subjects. Blood was drawn after 4hrs for measurement of lipid profile. The fasting lipid profile in type 2 diabetes mellitus differed from controls only in a significantly lower HDL value. There was no significant difference in any other lipid parameters. Significant postprandial lipid abnormalities were observed in the diabetic subjects particularly triglycerides (P–0.0001). Postprandial hypertriglyceridemia was directly correlated with BMI and glycaemic control. Postprandial hypertriglyceridemia was not correlated with age of the patient and duration of diabetes
Pages: 294-298  |  1114 Views  349 Downloads
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