Vol. 2, Issue 8 (2015)
Adverse Effects of Antimalarial Drug – alpha/beta Artether on Growth of Developing Chick Embryo
Author(s): Lavlesh Kumar Mittal, R.K. Ashoka, Vishram Singh, Sushma Tomar, Abhibhushan Mishra
Abstract: α/β artether is one of the most commonly antimalarial drug used worldwide to treat chloroquine resistant malaria and malaria falciparum. Artemisinin are the concentrates of artemisia plant found in china also called as Qinghaosu, and its subordinates are a group of drugs that have the most rapid action of all current drugs against Plasmodium falciparum, and α/β artether is one of its subordinates. In present study was performed on 153 eggs and divided in to experimental A and B and control groups a & b. The eggs of experimental groups were exposed to α/β artether on 5th day of incubation with doses of 0.12mg and o.24mg respectively. Whereas the control groups were treated with same amount of normal saline. On 20th day of incubation the eggs were broken and embryos were removed. The results showed no significant gross anatomical malformations but the experimental groups showed more mortality percentage, growth retardation and delayed growth.