Vol. 2, Issue 8 (2015)
Synthesis, Antimicrobial of N-[4-(4-Arylidene)-2-(4-X-Phenyl)-5-Oxo-4, 5-Dihydro-Imidazol-1-Yl] - Benzenesulfonamides
Author(s): Redha I. Hussein Al-Bayati, Kawkab Y. Saour, Jaafar Sataar Shia
Abstract: A novel series of (1a-e and 2a-e) were synthesized and characterized using IR, ¹HNMR and C¹³NMR. These compounds were in vitro screened against several bacterial species as well as Candida albicans, the common fungi species and found exhibiting moderate to potent activity. The newly synthesized sulfonamide derivatives were evaluated. Sulfonamide derivatives have been prepared by added p- toluenesulfonyl chloride or benzenesulfonyl chloride to the mixure of N-aminoimidazoline in pyridine was added drop wise at 0 ◦C. The resulting solution was stirred at room temperature for 7 hr. the reaction monitored by TLC. At the end of this period, the reaction solution was poured into mixture of ice and concentrated hydrochloride acid and water; the yellow colored precipitate was recovered. Washed with dilute hydrochloric acid and water, and recrystallized from the ethanol: water.