Vol. 2, Issue 8 (2015)
Original Article - Role of Serum Iron and Serum Ferritin in Type II Diabetes
Author(s): Sanjay Dhawale, Satyam Singh Jayant, Rakesh gaharwar
Abstract: Aims and objectives- to study the role of serum iron and ferritin in diabetics and its correlation with duration glycemic status, complications and medication status. Material and methods- this study was carried out in the Department of Medicine, G.R. Medical College and J.A. Group of Hospitals, Gwalior with ethical approval. This study included 50 diagnosed patients of diabetes mellitus belonging to various age groups and both sexes, and 25 age and sex matched healthy control cases were taken. All cases and control were subjected to detailed clinical history and, Clinical history and examination regarding duration of diabetes and treatment taken and history of other diseases and diabetic complication. inclusuion, exclusion and diagnostic criteria was followed and all patients were planned for routine and special laboratory investigations and then data was studied and results are as follows. Results- The mean age for the patients was 55.30yrs, whereas the mean age for the control group was 53.28yrs.Among diabetic patients, out of 50 individuals 32 were male and 18 were female. In control group, there were 16 male and 9 female individuals. The mean serum ferritin level in diabetic group was 170.242ng/ml and in control group was 43.28ng/ml. The mean serum iron of patients (group 1) was 110.884mcg/dl and that of group 2 was 75.8 mcg/dl. The difference was statistically highly significant for both serum ferritin and serum iron (P < 0.001 and P=0.014 respectively). A statistically significant difference was found in the serum ferritin and serum iron levels (P=0.044 and P=0.008 respectively) between the male and female patients (P=0.044 and P=0.008 respectively).The correlation of serum ferritin and serum iron levels with HbA1C was done. Both serum ferritin and serum iron levels did not show any correlation with HbA1C (P=0.985 and P=0.463 respectively).No significant correlation was found between serum ferritin and serum iron levels and duration of diabetes. Significant correlation was found between serum ferritin and serum iron levels and increasing number of complications of diabetes (P=0.002 and P=0.005 respectively). Patients not taking any regular treatment had significantly higher levels of serum ferritin and serum iron than those taking regular treatment. But no significant difference was seen in serum ferritin and serum iron levels among those taking OHA and those on insulin. Conclusion-Increased levels of serum ferritin and serum iron were observed in diabetic patients in our study adding credibility to the hypothesis that iron metabolism might participate in the etiology of insulin resistance. Levels of serum ferritin and serum iron were not correlating with the glycemic control of diabetic patients (HbA1c) and according to our study hence could not be used for the same.