Evaluation of Anti-arthritic potential of Adansonia digitata seed extract
V.Thiyagarajan, P. Muthusamy, N. Jayshree, R. Vijaya Bharathi
Adansonia digitata (Baobab) is a large deciduous tree up to 25m in height and may live for more than hundred years. It is a tree species native to Africa. The common English names for the Baobab include Dead rat tree, monkey bread tree. Upside-down tree and cream of tartar tree. In traditional system of medicine Adansonia digitata the seeds are used for various aliments including anti-inflammatory, analgesic, anti-pyretic activity, anti-oxidant, anti-diarrhoeal and anti-dysentry and trypanosmal activity. The present study evaluates the effect of the ethanolic extract of â€œAdansonia digitataâ€ seeds on the Fruendâ€™s Complete Adjuvant (CFA) induced arthritis. The parameters assessed were rat paw edema, body weight changes, hematological parameters histopathology of proximal interphalangeal joints and radiology of hind legs. In CFA induced arthritic control rats, there was significant increase in rat paw volume and decrease in body weight, where as Adansonia digitata seed extract treated groups showed a significant reduction of paw volume and gain in body weight. The altered haematological parameters (Hb, RBC, WBC and ESR) in the arthritic control rats were significantly brought back to near normal by the Adansonia digitata seed treatment at the dose level of 200 mg/kg and 400 mg/kg in both developing and developed phases of arthritis. Further the histopathological and radiological studies revealed the significant anti-arthritic activity of Adansonia digitata seed as indicated by fewer abnormalities in these groups when compared to the arthritic control group. In conclusion, Adansonia digitata seed extract at the specified dose evel of 200 mg/kg and 400 mg/kg showed reduction in rat paw volume and it could significantly normalize the haematological abnormalities in adjuvant induced arthritis rats in both developing and developed phases of CFA induced arthritis. Further the histopathological and radiological studies confirmed the anti-arthritic activity of â€œAdansonia digitataâ€.