Vol. 2, Issue 11 (2015)
The effect of Maerua pseudopetalosa ethanolic extract on glucose tolerance and glucose uptake in rat hemidiaphragm
Author(s): Hayder Elthaher Sulaiman, Tarig Elhadyah, Wahab Hassan Hamed, Ahmed Saeed Kabbashi, Mohammed Ahmed Abass
Abstract: Maerua pseudopetalosa (Gilg and Bened.) De Wolf (Family: Capparaceae) is a medicinal plant of great repute in South Central Sudan. The roots are used for cough and for treatment of tumors. The roots of M. pseudopetalosa showed activity against some bacterial strains. The present study was carried to evaluate the effect of 100, 200 and 400 mg/kg of ethanolic extract (80%) of Maerua pseudopetalosa roots in glucose-loaded wistar albino rats and dose of 0.1% of the extract in glucose uptake by using isolated rats hemidiaphgrams. The effect of the three doses 100, 200 and 400mg/kg was studied 1, 2 and 4 hours after loading the fasting rats with glucose. Their effects were compared to control rats administered with the vehicle and to a standard group administered with the standard drug glibenclamide 10mg/kg. The dose 100 mg/kg of the extract was found to be the most effective dose in models of experiments while the dose of 0.1% of aqueous extract showed significant effect on the glucose reuptake by the hemidiaphragm when administered together with insulin than the effect attained by either insulin or extract alone. The study concluded that M. pseudopetalosa ethanolic extract was found to have antihyperglycemic effect in vivo when evaluated in wistar albino rats and enhanced re-uptake of glucose when used together with insulin in isolated rat hemidiaphragm.