Vol. 2, Issue 10 (2015)
Impact of Phonophoresis Therapy in Hematological Changes on Freund’s Adjuvant Induced Arthritic Rats
Author(s): P Lakshmi Kanth, V Elango
Abstract: Haematological profiles of blood can provide important information about the internal environment of the organism. In the present investigation the effect of ultrasound and phonophoresis on the blood components is determined in Freund’s adjuvant induced arthritic rats. The decrease in RBC count, Hb and ESR observed in the present investigation could be described are retarded haemopoisis, destruction and shrinkage of RBC. MCV, MCH and MCHC showed significant decrease in the present investigation, due to destruction of RBC (size and shape) and decrease in Hb synthesis and hemoglobin content. These symptoms imply the microcytic - hypo chromic anemia. A decreased percentage of neutrophils in peripheral blood observed in animals with Freund’s adjuvant induced arthritic rats may suggest, neutrophils involves in phagocytosis during Freund’s adjuvant intoxication, during which some of the neutrophils might have ruptured. The result of the present experiment indicates that phonophoresis therapy possesses significant antiarthritic activity as compared with ultrasound application. The possible mode of action of anti- arthritic activity of phonophoresis therapy appears to be enhanced membrane permeability and inhibit the inflammatory reactions and improving heamatological parameters. Thus, the increase in the Hb and RBC count brought about by ultrasound and phonophoresis treatment further support its anti-arthritic effect. The potential phonophoresis therapy might be due to various ingredients in Plumbago zeylanica extract acting synergistically and working in concert for overall antiarthritic activity.