Understanding the knowledge level and practices about blood donation among medical students is essential since they are expected to convey the information regarding the need for voluntary blood donation to the general population. Objectives - To assess the awareness level and practices regarding blood donation among medical students. A cross sectional descriptive study was done among 135 students studying Final Year Medicine in a medical college during the month of October 2013. A pre tested and semi structured questionnaire was used. Chi square test and Fisher's exact test were used for analysis. Results - The results revealed that students were well aware of the minimum age limit for blood donation (95.5 percent), frequency of blood donation (89.6 percent) & recommended type of blood donation (94.8 percent). However, the maximum age limit (8.8 percent) & minimum weight (34 percent) were areas of poor knowledge among the students. 54 percent of the students had ever donated blood. The reasons attributed by those who had not donated blood were anaemia (41.9 percent), underweight (14.5 percent) and fear (4.8 percent). There was no significant difference in awareness among males and females, but blood donation practices were found to be significantly higher among males.